Ribosome-Mediated Translational Reprogramming in Salmonella Pathogenesis
살모넬라 발병 기전에서의 리보솜 매개 번역재편성
- 주제(키워드) Salmonella Typhimurium , Ribosome-mediated , Peptide deformylase (PDF) , Elongation factor P (EF-P) , Programmed ribosomal frameshifting , Ribosome heterogeneity
- 발행기관 고려대학교 대학원
- 지도교수 이은진
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 박사
- 학과 및 전공 대학원 분자생명과학과
- 세부전공 분자생물학전공
- 원문페이지 132 p
- 실제URI http://www.dcollection.net/handler/korea/000000308329
- UCI I804:11009-000000308329
- DOI 10.23186/korea.000000308329.11009.0301865
- 본문언어 영어
목차
ABSTRACT ···························································································· ⅰ
국문 초록 ····························································································· ⅲ
PREFACE ···························································································· ⅶ
TABLE OF CONTENTS ·········································································· ⅷ
LIST OF FIGURES··················································································· ⅸ
LIST OF TABLES ··················································································· ⅺ
NOMENCLATURE ················································································ ⅻ
CHAPTER Ⅰ. OVERVIEW ·········································································· 1
1.1 Salmonella Typhimurium pathogenesis and host environments ··························· 1
1.2 The ribosome as a regulatory hub in bacterial translation ·································· 3
1.3 Regulation at translation initiation and post-initiation processing ························ 4
1.4 Regulation at translation elongation··························································· 4
1.5 Regulation at translation termination and ribosome heterogeneity ······················· 4
1.6 Aims of this study ················································································ 5
CHAPTER Ⅱ. Accumulation of N-formylated PspA couples membrane stress response to survival in Salmonella lacking peptide deformylase ············································· 7
CHAPTER Ⅲ. Elongation factor P controls ribosomal frameshift of a Salmonella antimicrobial resistance gene ······································································· 30
CHAPTER Ⅳ. A biphasic ribosome switching strategy orchestrates the transition from survival to proliferation in Salmonella pathogenesis ············································ 82
CHAPTER Ⅴ. CONCLUSION ··································································· 113
