레서핀 반복 투여를 통한 제브라피쉬 우울증 모델
Chronic Reserpine Administration for Depression Modeling in Zebrafish
- 주제(키워드) Reserpine , Depression , Zebrafish , Animal model , Experimental model.
- 발행기관 대한생물정신의학회
- 발행년도 2023
- 총서유형 Journal
- DOI http://dx.doi.org/10.22857/kjbp.2023.30.1.003
- KCI ID ART002952278
- 본문언어 한국어
초록/요약
Objectives This study aims to develop valid experimental models for depression through chronic reserpine exposure to zebrafish (Danio rerio). Methods The effect of chronic reserpine on zebrafish behavior in the novel tank was examined. Changes of gene expression on telencephalon were also investigated. Results Chronic reserpine (40 mg/L, 7 days) induced overt behavioral effects, but markedly reduced activity, resembling motor retardation in depression. In telencephalon of zebrafish, gene expression associated with monoamine oxidase and norepinephrine transporter was decreased. Expression of serotonin transporter gene was increased. Conclusions Our results show that the pharmacological model of depression in zebrafish can induce not only behavioral changes, but also monoamine changes in the homology of human mood regulation centers.
more