Palmoplantar pustulosis, Principal component analysis, Psoriasis, Pustular pso- riasis
- 주제(키워드) Body regions , Psoriasis , Treatment , Ustekinumab
- 발행기관 대한피부과학회
- 발행년도 2022
- 총서유형 Journal
- KCI ID ART002807299
- 본문언어 영어
초록/요약
Background: In psoriasis treatment, not all body regions improve simultaneously after clinical interventions. Objective: This study was aimed at evaluating clinical responses across body regions, which may differentially influence patient treatment plans. Methods: This prospective, observational, and multi-center study was conducted in Ko- reans who adhered to ustekinumab treatment based on criteria per local label and reim- bursement guidelines. A total of 581 were included in this analysis. Results: The mean (±standard deviation) psoriasis area severity index (PASI) score at baseline, age, disease duration, and body surface area (%) were 18.9±9.69, 44.2±13.29 years, 11.3±9.65 years, and 27.8±17.83, respectively. Across the head and neck, upper extremities, trunk, and lower extremities, the correlation between the PASI sub-scores for the upper and lower extremities was the highest (r=0.680). The mean PASI sub-score for the lower extremities was the highest at baseline. PASI90 and PASI100 scores were the highest for the head and neck region, indicating the highest response rates, while those for the lower extremities were consistently low at all visits. Conclusion: We found differences in regional ustekinumab responses, with the lower ex- tremities being the most difficult to treat. These findings should be considered in psoriasis treatment.
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