PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances
PCL microspheres containing magnesium hydroxide for dermal filler with enhanced physicochemical and biological performances
- 주제(키워드) Dermal filler Polycaprolactone (PCL) microspheres Magnesium hydroxide (MH) Anti-inflammation Anti-senescence
- 발행기관 한국공업화학회
- 발행년도 2019
- 총서유형 Journal
- DOI http://dx.doi.org/10.1016/j.jiec.2019.07.043
- KCI ID ART002542464
- 본문언어 영어
초록/요약
Polymeric microspheres containing magnesium hydroxide (MH) was developed as a functional dermalfiller with enhanced physicochemical and biological performances. In this study, polycaprolactone (PCL)and MH microspheres (PCL/MH) were uniformly produced with approximately 50 mm in size through asimplefluidic device. In the PCL/MH composite, MH effectively neutralized the acidic degradationproducts generated by polymer degradation. In in vitro cell experiments, when MH was treated withacidic decomposition product (i.e., 6-hydroxycaproic acid, HCA), the acidic pH was neutralized to inducewound healing along with inhibition of inflammation and senescence. Furthermore, MH promoted theproduction of collagen. These results suggest that the PCL/MH microspheres have great potential as afunctional dermalfiller for skin esthetics and facial plastic surgery.
more