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Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?

Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?

초록/요약

ObjectiveThis study aimed to determine the association between preeclampsia and the postpartum development of metabolicsyndrome based on the pre-pregnancy status. MethodsKorean women who delivered their first child between January 1, 2011, and December 31, 2012, were enrolled. Allsubjects underwent a national health screening examination conducted by the National Health Insurance Corporation1 or 2 years prior to their first delivery and within 2 years after their first delivery. ResultsAmong the 49,065 participants, preeclampsia developed in 3,391 participants (6.9%). The prevalence of metabolicsyndrome was higher postpartum in women with preeclampsia than in those without preeclampsia (4.9% vs. 2.7%, respectively, P<0.001). Through the pre-pregnancy to postpartum period, women with preeclampsia had agreater increase in gestational weight retention, body mass index, waist circumference, systolic blood pressure,and triglyceride levels and a greater decrease in high-density lipoprotein cholesterol levels than women withoutpreeclampsia. Preeclampsia was associated with an increased risk of the postpartum development of metabolicsyndrome in women without pre-pregnancy metabolic syndrome (odds ratio, 1.28; 95% confidence interval, 1.05–1.56). However, preeclampsia was not associated with postpartum metabolic syndrome in women with pre-pregnancymetabolic syndrome or 2 components of metabolic syndrome. ConclusionIn this study, preeclampsia was associated with the postpartum development of metabolic syndrome in womenwithout pre-pregnancy metabolic syndrome. However, the effects were attenuated by predisposing risk factors in thepre-pregnancy period.

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