Non-convulsive seizure related to Cremophor EL™-free, polymeric micelle formulation of paclitaxel: a case report
Non-convulsive seizure related to Cremophor EL™-free, polymeric micelle formulation of paclitaxel: a case report
- 주제(키워드) Paclitaxel , Seizures , Neurotoxicity , Cremophor
- 발행기관 대한산부인과학회
- 발행년도 2018
- 총서유형 Journal
- KCI ID ART002346814
- 본문언어 영어
초록/요약
Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. Althoughperipheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity israrely reported. When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), asurfactant-containing vehicle used for paclitaxel administration. In the present report, we discuss the case of a 72-yearoldwoman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrELfree,polymeric micelle formulation of paclitaxel. One week after her fourth round of chemotherapy, she experienceda transient episode of aphasia for 45 minutes. Electroencephalography demonstrated epileptiform discharges. To ourknowledge, this is the first reported case of seizure associated with a CrEL-free formulation of paclitaxel. Althoughrare, patients and clinicians should remain aware of the risk of non-convulsive seizure following infusion of thispaclitaxel formulation.
more