A Structural View of Xenophagy, a Battle between Host and Microbes
A Structural View of Xenophagy, a Battle between Host and Microbes
- 주제(키워드) Galectin-8 , Legionella , NDP52 , RavZ , Salmonella
- 발행기관 한국분자세포생물학회
- 발행년도 2018
- 총서유형 Journal
- KCI ID ART002314203
- 본문언어 영어
초록/요약
The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy. Several molecules have been identified and their structural investigation has enabled the comprehension of these mechanisms at the molecular level. In this review, we focus on one example of host autophagy and the other of bacterial defense: the autophagy receptor, NDP52, in conjunction with the sugar receptor, galectin-8, plays a critical role in targeting the autophagy machinery against Sal-monella; and the cysteine protease, RavZ secret-ed by Legionella pneumophila cleaves the LC3-PE on the phagophore membrane. The structure-function relationships of these two examples and the directions of future research will be dis-cussed.
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