Effects of Psychotropic Drugs on Seizure Threshold during Electroconvulsive Therapy
Effects of Psychotropic Drugs on Seizure Threshold during Electroconvulsive Therapy
- 주제(키워드) Electroconvulsive therapy , Seizure threshold , Antipsychotics , Antidepressants
- 발행기관 대한신경정신의학회
- 발행년도 2017
- 총서유형 Journal
- KCI ID ART002262829
- 본문언어 영어
초록/요약
Objectives: To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. Methods: We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast). Results: Multivariate regression analyses showed associations between initial ST and the total chlorpromazine-equivalent dose of antipsychotics (β=0.363, p<0.05). The total fluoxetine-equivalent dose of antidepressants was associated with ΔST10th (β=0.486, p<0.01) and mean ΔSTlast (β=0.472, p<0.01). Conclusion: Our study elucidated possible effects of psychotropic drugs on ST shifts. Larger doses of antipsychotics were associated with higher initial ST, whereas higher doses of antidepressants were associated with stronger shifts in ST.
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