A Case of Cytomegalovirus Infection in a Neonate with Osteopetrosis : 골화석증에 동반된 거대세포바이러스 감염의 1례
A Case of Cytomegalovirus Infection in a Neonate with Osteopetrosis
- 주제(키워드) Osteopetrosis , Cytomegalovirus infection , Infant
- 발행기관 대한소아감염학회
- 발행년도 2016
- 총서유형 Journal
- UCI G704-SER000001478.2016.23.1.009
- KCI ID ART002101102
- 본문언어 영어
초록/요약
Infantile osteopetrosis is a rare congenital disorder caused by abnormal bone resorption. Patients with osteopetrosis can have severe anemia, thrombocytopenia, hepatosplenomegaly, rickets, visual impairment, and deafness. Cytomegalovirus also can cause a congenital infection with anemia, thrombocytopenia, hepatosplenomegaly, and calcifications in the brain. We report a 38-day-old infant with severe hepatospleno megaly, thrombocytopenia, hypocalcemia, and growth failure. Real time polymerase chain reaction detected cytomegalovirus in the plasma. Skeletal radiography revealed generalized bone sclerosis. He was diagnosed with osteopetrosis along with cytomegalovirus infection. Only the test for mutation of the CLCN7 gene, representing the most common and heterogeneous form of osteopetrosis, was available, and the result was negative. With supportive care and antiviral treatment, severe thrombocytopenia due to the cytomegalovirus infection almost normalized despite the possible immunosuppression caused by osteopetrosis. We present the first report of an infant who suffered from osteopetrosis and CMV infection which was successfully treated by long term antiviral agent therapy.
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