Frontoparietal Cortical Thinning in Respiratory-Type Panic Disorder: A Preliminary Report
Frontoparietal Cortical Thinning in Respiratory-Type Panic Disorder: A Preliminary Report
- 주제(키워드) Cortical thickness , FreeSurfer , Panic disorder , Respiratory type.
- 발행기관 대한신경정신의학회
- 발행년도 2016
- 총서유형 Journal
- UCI G704-002181.2016.13.1.015
- KCI ID ART002076050
- 본문언어 영어
초록/요약
ObjectiveaaMany evidences raise the possibility that the panic disorder (PD) patients with respiratory subtype (RS) may have characteristic structural abnormalities. We aimed to explore the structural differences between PD patients with and without the respiratory symptoms. MethodsaaPatients with PD were recruited from the Department of Psychiatry at Korea University Anam Hospital. Respiratory subtype (RS) was diagnosed when at least 4 out of 5 of the following respiratory symptoms were present during the panic attack: fear of dying, chest pain/discomfort, shortness of breath, paresthesias, and a choking sensation. We acquired high-resolution MRI scans and used FreeSurfer to obtain a measure of cortical thickness for each patient. ResultsaaCluster based analysis revealed significantly decreased cortical thickness in the left hemisphere in the caudal-middle-frontal, superior frontal, and posterior parietal areas in the RS group. No significant difference was observed in any of the limbic areas. ConclusionaaRespiratory symptoms of panic disorder were associated with a reduction in cortical thickness in the left frontal and parietal areas. This finding leads to the assumption that the frontoparietal network is the crucial component in a larger cortical network underlying the perception of dyspnea in RS.
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