Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea
Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea
- 주제(키워드) Diphosphonates , Drug holiday , Fractures bone , Osteoporosis
- 발행기관 대한골대사학회
- 발행년도 2015
- 총서유형 Journal
- UCI G704-SER000003105.2015.22.4.007
- KCI ID ART002053735
- 본문언어 영어
초록/요약
Bisphosphonates have been widely used in the treatment of osteoporosis with robust data from many placebo-controlled trials demonstrating its efficacy in fracture risk reduction over 3 to 5 years of treatment. Although bisphosphonates are generally safe and well tolerated, concerns have emerged about the adverse effects related to its longterm use, including osteonecrosis of the jaw and atypical femur fractures. Because bisphosphonates are incorporated into the skeleton and continue to exert an anti-resorptive effect for a period of time after the discontinuation of drugs, the concept of a “drug holiday” has emerged, whereby the risk of adverse effects might be decreased while the patient still benefits from anti-fracture efficacy. As randomized clinical trial evidence is not yet available on who may qualify for a drug holiday, there is considerable controversy regarding the selection of candidates for the drug holiday and monitoring during a drug holiday, both of which should be based on individual assessments of risk and benefit. This statement will provide suggestions for clinicians in South Korea on the identification of possible candidates and monitoring during a bisphosphonate drug holiday.
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