Impact of White Matter Lesions on Depression in the Patients with Alzheimer’s Disease
Impact of White Matter Lesions on Depression in the Patients with Alzheimer’s Disease
- 주제(키워드) Alzheimer’s disease , White matter lesions , Depression
- 발행기관 대한신경정신의학회
- 발행년도 2015
- 총서유형 Journal
- UCI G704-002181.2015.12.4.010
- KCI ID ART002046708
- 본문언어 영어
초록/요약
ObjectiveaaComorbid depression is common in patients with Alzheimer’s disease (AD). An increase in white matter lesions (WMLs) has been associated with depression in both elderly individuals with normal cognition and patients with Alzheimer’s disease. We investigated whether the severity and location of WMLs influence the association between WMLs and comorbid depression in AD. MethodsaaWe enrolled 93 AD patients from Seoul National University Bundang Hospital. We administered both the Mini International Neuropsychiatric Inventory (MINI) and the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K) clinical and neuropsychological battery. Subjects also underwent brain magnetic resonance imaging (MRI). We diagnosed AD according to the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association. We diagnosed depressive disorders according to the DSM-IV diagnostic criteria, and evaluated the severity of depressive symptoms using the Korean version of the Geriatric Depression Scale (GDS-K). We quantified the WML volumes from the brain MRI using a fully automated segmentation algorithm. ResultsaaThe log of the WML volume in the frontal lobe was significantly associated with depressive disorders (odds ratio=1.905, 95% CI=1.027–3.533, p=0.041), but not with the severity of depressive symptoms as measured by the GDS-K. ConclusionaaThe WML volume in the frontal lobe conferred a risk of comorbid depressive disorders in AD, which implies that comorbid depression in AD may be attributed to vascular causes.
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