Effect of Magnesium Hydroxide Nanoparticles with Rod and Plate Shape on Mechanical and Biological Properties of Poly(L-lactide) Composites
Effect of Magnesium Hydroxide Nanoparticles with Rod and Plate Shape on Mechanical and Biological Properties of Poly(L-lactide) Composites
- 주제(키워드) poly(L-lactide) , magnesium hydroxide , shape , mechanical property , inflammation.
- 발행기관 한국고분자학회
- 발행년도 2014
- 총서유형 Journal
- UCI G704-000117.2014.22.9.013
- KCI ID ART001914004
- 본문언어 영어
초록/요약
Two kinds of magnesium hydroxide (Mg(OH)2) rods (Mg-Rod, 150 and 350 nm in size) and plates (Mg-PL,60 and 300 nm) were prepared, and blended with poly(L-lactide) (PLLA) to obtain PLLA/Mg(OH)2 composites toinvestigate the effect of the shape and size of Mg(OH)2 particles. The structure, morphology, pH change, thermaland mechanical properties, cytotoxicity, and inflammation of Mg(OH)2 control and PLLA/Mg(OH)2 compositeswere evaluated. PLLA/Mg-Rod150 (30%) composite showed a 50% higher tensile strength and a 45% improvedmodulus as compared with PLLA/Mg-PL300 30% composite. Although Mg-Rods displayed similar cell viability(above 80%) as compared to Mg-PLs, the expression levels of TNF-α from Mg-PL60 gradually increased withincreasing concentrations from 1 to 300 μg. This indicates that Mg-PL60 had a potential cytotoxicity due to endocytosis. In addition, the byproduct of PLLA/Mg-Rods composite was more effectively neutralized than that of thePLLA/Mg-PLs composite, but cell viability and the expression levels of TNF-α were similar. Therefore, the use ofour PLLA/Mg-Rod composite system would be a promising strategy to prevent the current fatal problems in biomedicalapplications including biodegradable implants such as stents.
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