The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer
The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer
- 주제(키워드) Small cell lung carcinoma , Limited-stage , Chemoradiotherapy , Start of any treatment until the end of radiotherapy
- 발행기관 대한내과학회
- 발행년도 2013
- 총서유형 Journal
- UCI G704-001640.2013.28.4.006
- KCI ID ART001783590
- 본문언어 영어
초록/요약
Background/Aims: Chemotherapy combined with radiation therapy is the standard treatment for limited stage small cell lung cancer (LS-SCLC). Although numerous studies indicate that the overall duration of chemoradiotherapy is the most relevant predictor of outcome, the optimal chemotherapy and radiation schedule for LS-SCLC remains controversial. Therefore we analyzed the time from the start of any treatment until the end of radiotherapy (SER) in patients with LS-SCLC. Methods: We retrospectively analyzed 29 patients diagnosed histologically with LS-SCLC and divided them into two groups: a short SER group (< 60 days) and a long SER (> 60 days) group. Patients were treated with irinotecan-based chemotherapy and thoracic radiotherapy. Results: Sixteen patients were in the short SER group and 13 patients were in the long SER group. Short SER significantly prolonged survival rate (p = 0.03) compared with that of long SER. However, no significant differences in side effects were observed. Conclusions: Short SER should be considered to improve the outcome of concurrent chemoradiotherapy for LS-SCLC.
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