미래의 항우울제 : Future Antidepressants
Future Antidepressants
- 주제(키워드) Antidepressant · Depression · HPA axis · Neurotrophic factor · Glutamate · Neurokinin ·Phosphodiesterase · Cytokines , 항우울제·우울증·시상하부-뇌하수체-부신피질축·신경영양성인자·글루탄산염·뉴로키닌· 포스포디에스테라제·사이토카인
- 발행기관 대한생물치료정신의학회
- 발행년도 2011
- 총서유형 Journal
- UCI G704-001697.2011.17.2.012
- KCI ID ART001615119
- 본문언어 한국어
초록/요약
Recent advances in research on depression have confirmed that it is common, chronic, recurrent and disabling men-tal disorder. The treatment of depression has gained growing importance because of its major impact on the patient’s wellbeing, personal and social achievements. Recently, as an increasing number of antidepressants of various types continue to be developed for the treatment of depression, psychopharmacotherpy is the major approach to depression in clinical setting. Unfortunately, there are clear limitations to the currently approved pharmacotherapies of depression, including the fact that they are all essentially monoamine based, have modest efficacy and a relatively slow onset of efficacy, and suffer from significant tolerability issues. Recently, several promising hypotheses of depression and antidepressant action have been formulated. These hypotheses are based on dysregulation of hypothalamic-pituitary-adrenal(HPA) axis, neurotrophic mechanisms, glutamate, neurokinin, phosphodiesterase, cytokines. This article reviews these most promising novel mechanisms that are not represented in compounds currently approved for de-pression in either the United States or Europe and that may represent the future of the psychopharmacologic treatment of depression.
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