Conductivity of DNA with a Single Base Pair Mismatch
Conductivity of DNA with a Single Base Pair Mismatch
- 주제(키워드) Conductivity , DNA base pair mismatch , Molecular electronics
- 발행기관 한국물리학회
- 발행년도 2011
- 총서유형 Journal
- UCI G704-000411.2011.58.6.015
- KCI ID ART001557956
- 본문언어 영어
초록/요약
We examine the effect of an intervening base pair mismatch on the conductivity of a homogeneous DNA duplex. The mismatch is modeled by introducing three independent parameters based on experimental observation which indicate that the effects of a mismatch are localized mostly in the vicinity of the mismatch. We find that an interruption of the π-stacking and an on-site energy deviation due to the mismatch cause a reduction of the conductivity in DNA while a destabilized hydrogen bonding has much less effect. Also, the results depend on the locations of electron reservoirs, i.e., whether or not they are attached to the same strand.
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