Nano and micro structures for label-free detection of biomolecules
Nano and micro structures for label-free detection of biomolecules
- 주제(키워드) nano/micro structure , label-free , biosensors , resonator , nanowire FET
- 발행기관 한국센서학회
- 발행년도 2010
- 총서유형 Journal
- UCI G704-000913.2010.19.6.010
- KCI ID ART001495941
- 본문언어 영어
초록/요약
Nano and micro structure-based biosensors are promising tool for label-free detection of biomolecular interactions with great accuracy. This review gives a brief survey on nano and micro platforms to sense a variety of analytes such as DNA, proteins and viruses. Among incredible nano and micro structure for bio-analytical applications, the scope of this paper will be limited to micro and nano resonators and nanowire field-effect transistors. Nanomechanical motion of the resonators transducers biological information to readable signals. They are commonly combined with an optical, capacitive or piezo-resistive detection systems. Binding of target molecule to the modified surface of nanowire modulates the current of the nanowire through electrical field-effect. Both detection methods have advantages of label-free, real-time and high sensitive detection. These structures can be extended to fabricate array-type sensors for multiplexed detection and highthroughput analysis. The biosensors based on these structures will be applied to lab-on-a-chip platforms and point-ofcare diagnostics. Basic concepts including detection mechanisms and trends in their fields will be covered in this review.
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