Subcutaneous botulinum toxin type a injection for chronic medial knee pain with ostheoarthritis
Subcutaneous botulinum toxin type a injection for chronic medial knee pain with ostheoarthritis
- 주제(키워드) botulinum toxin , clinical trial , knee pain
- 발행기관 대한마취통증의학회
- 발행년도 2009
- 총서유형 Journal
- UCI G704-SER000009362.2009.4.3.016
- KCI ID ART001417300
- 본문언어 영어
초록/요약
Background: This study was designed to evaluate the efficacy of subcutaneous Botulinum toxin type A (BoNT-A) injection for treating chronic medial knee pain with osteoarthritis. Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted at a university hospital in Korea. The subjects suffering from chronic medial knee pain with osteoarthritis were randomly allocated to either the BoNT-A (treatment, n = 23) group or the normal saline (placebo, n = 27) group. Injections were given to 10 points per unilateral knee along the course of the saphenous nerve. A total of 90 units of BoNT-A (60 units at baseline and 30 units after 1 week) was given for treating unilateral knee pain and a total of 180 units of BoNT-A was given for treating bilateral knee pain. The placebo group received the same volume of normal saline. Results: The Visual Analog Scale (VAS) pain score was significantly decreased in both the BoNT-A and normal saline groups 1, 4 and 12 weeks after injection. After adjusting for covariates, BoNT-A had a 0.788 times higher effect to decrease the VAS score than did normal saline, but the effect was marginally significant (P = 0.050). Conclusions: Subcutaneous injection along the course of the saphenous nerve significantly reduces chronic medial knee pain. The pain reduction effect of BoNT-A is higher than that of placebo, but the effect is marginally significant.
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