기계환기로 인한 급성 폐손상에서 poly(ADP-ribose) polymerase-1의 역할 : The Role of Poly(ADP-ribose) Polymerase-1 in Ventilator-Induced Lung injury
The Role of Poly(ADP-ribose) Polymerase-1 in Ventilator-Induced Lung injury
- 주제(키워드) Ventilator-induced lung injury , Acute lung injury , Poly (ADP-ribose) polymerase-1 , Poly (ADP-ribose) polymerase-1 inhibitor , Ventilator-induced lung injury , Acute lung injury , Poly (ADP-ribose) polymerase-1 , Poly (ADP-ribose) polymerase-1 inhibitor
- 발행기관 대한결핵및호흡기학회
- 발행년도 2006
- 총서유형 Journal
- UCI G704-000421.2006.60.4.008
- KCI ID ART001011305
초록/요약
Background : Reactive oxygen species (ROS) take center stage as executers in ventilator-induced lung injury (VILI). The protein with DNA-damage scanning activity, poly (ADP-ribose) polymerase-1 (PARP1), signals DNA rupture and participates in base-excision repair. Paradoxically,overactivation of PARP1 in response to massive genotoxic injury such as ROS can induce cell death through beta
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