The Solid-Phase Synthesis of Amino Acid-Derived Diacetylene Lipids
The Solid-Phase Synthesis of Amino Acid-Derived Diacetylene Lipids
- 주제(키워드) solid-phase synthesis , diacetylene , amino acids.
- 발행기관 한국고분자학회
- 발행년도 2005
- 총서유형 Journal
- UCI G704-000117.2005.13.3.001
- KCI ID ART000963394
- 본문언어 영어
초록/요약
We prepared amino acid-derived diacetylene monomers using solid-phase organic synthesis. The solid-phase synthetic method allowed for the rapid and efficient preparation of functional diacetylenes. Amino acids hav ing hydrophobic sidechains such as alanine, leucine, and phenylalanine, as well as hydrophilic sidechains such as aspartic acid and lysine, were successfully coupled to the diacetylene lipid. The diacetylene monomers prepared in this way were subjected to routine procedures for the generation of polydiacetylene vesicles. Depending on the nature of the side-chains, pink to blue colored polydiacetylenes were generated.
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