Changes of Coronary Blood Flow in Vasospastic Angina under Cold Stimulation by Transthoracic Doppler Echocardiography : Changes of Coronary Blood Flow in Vasospastic Angina under Cold Stimulation by Transthoracic Doppler Echocardiography
Changes of Coronary Blood Flow in Vasospastic Angina under Cold Stimulation by Transthoracic Doppler Echocardiography
- 주제(키워드) Angina Pectoris , Variant , Coronary Vasospasm , Cold Stimulation , Regional Blood Flow , Microvascular Function , Echocardiography , Doppler
- 발행기관 대한의학회
- 발행년도 2005
- 총서유형 Journal
- UCI G704-000345.2005.20.2.028
- KCI ID ART001111982
- 본문언어 영어
초록/요약
This study was done to evaluate changes of microvascular function under cold stim-ulation by measuring coronary flow velocities (CFVs) in vasospastic angina (VA) patients using transthoracic Doppler echocardiography (TTDE). 14 patients with VA and 15 healthy controls were included. CFVs were measured at the distal left anterior descending coronary artery by TTDE at baseline and under cold stimulation. Hyper-emia was induced by intravenous adenosine infusion (140 g/kg/min). At baseline, CFVs and coronary flow reserve (CFR) were not different between controls and VA patients. Under cold stimulation, the degree of increment of CFV with adenosine was lower in VA patients than in controls. Comparing baseline with cold stimulation, coro-nary flow reserve (CFR) increased (3.1 ±0.7 to 3.8 ±1.0, p=0.06) in controls. In con-trast, in VA patients, CFR was decreased (2.8 ±0.9 to 2.6 ±0.7, p=0.05) and coro-nary vascular resistance index markedly increased (0.35 to 0.43, p=0.01). Through-out the study, no patient experienced chest pain or ECG changes. In VA patients, CFR was preserved at baseline, but coronary blood flow increase in response to cold stimulation was blunted and CFR was decreased. These findings suggest that endothelial dependent vasodilation is impaired at the coronary microvascular and the epicardial artery level in VA under cold stimulation.
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