Propylthiouracil 약제 복용으로 유발된 미만성 폐출혈 1예 : A Case of Propylthiouracil Induced DiffusePulmonary Hemorrhage
A Case of Propylthiouracil Induced DiffusePulmonary Hemorrhage
- 주제(키워드) Propylthiouracil , ANCA , Diffuse alveolar hemorrhage , Propylthiouracil , ANCA , Diffuse alveolar hemorrhage
- 발행기관 대한결핵및호흡기학회
- 발행년도 2005
- 총서유형 Journal
- UCI G704-000421.2005.58.1.010
- KCI ID ART001117588
초록/요약
Propylthiouracil(PUT) is a drug which used at Grave's disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar he morrhage. We report the case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for two years. She had received a diagnosis of Grave's disease at two years ago. The serologic study was positive for ANCA with myeloperoxidase(MPO) specificity. Bronchoalveloar lavage(BAL) fluid analysis revealed hemosiderin- laden macrophages. Such findings suggested propylthiouracil induced dffuse pulmonary hemorrhage associated with antineutrophil cytoplasmic antibody. To our knowledge, this represents the first documentation in a case of PTU-induced diffuse pulmonary hemorrhage in Korea. (Tuberc Respir Dis 2005; 58:78-82)
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