혈관대치물 응용을 위한 소장점막하층의 체외 특성에 관한 기초연구 : In Vitro Characteristics of Small Intestinal Submucosa for Application as a Vascular Graft
In Vitro Characteristics of Small Intestinal Submucosa for Application as a Vascular Graft
- 주제(키워드) Small intestinal submucosa , Vascular graft , Heparin , Antithrombogenecity , Biocompatibility
- 발행기관 한국생체재료학회
- 발행년도 2003
- 총서유형 Journal
- UCI G704-001603.2003.7.4.005
- KCI ID ART001205037
초록/요약
Various vascular diseases inspire us to develop the ideal vascular substitute. Small intestinal submucosa (SIS) is a feasible and wide available matrix as biomaterials for the vascular substitutes. An in-vitro preliminary study for the mechanical and biological properties of the heparin bonded SIS as a vascular substitute was preceded by the development of the anti-thrombogenecity technique using heparin bonding methods. The study groups were divided, e.g., SIS group for fresh SIS; SIS-GA group for SIS treated with glutaraldehyde (GA); and SIS-GA-Heparin group for SIS treated with glutaraldehyde and heparin. The quantity analysis for heparin of the heparin bonded SIS shows stable concentration, e.g., 0.339±0.084 g/cm2. GA treated heparinized tissue (SIS-GA-Heparin) reveals highest digestion resistance to collagenase among the study groups. The data of the study for maximal stress show highest in SIS-GA-Heparin group (0.55 ±0.19 kg/mm2), and lowest in SIS group (0.28±0.07 kg/mm2). The data of the study for maximal strain show highest in SIS group (78.69±8.59%), and lowest in SIS-GA-Heparin group (34.85±6.51%). As concerns degree of heparinization, digestion resistance to collagenase and mechanical properties, GA treated heparinized tissue (SIS-GA-Heparin) is superior to the other types of SIS as a vascular substitutes. According to this study, further studies for the antithrombogenecity and patency rate are needed.
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