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반복적 스트레스에 의한 뇌내 corticotropin releasing factor 수용체(CRF-R1, CRF-R2)의 변동에 관한 연구 : Effects of Repeated Stress on Expression of Corticotropin Releasing Factor Type I and II Receptors

Effects of Repeated Stress on Expression of Corticotropin Releasing Factor Type I and II Receptors

초록/요약

Objectives : Corticotropin releasing factor (CRF) plays a primary role in coordinating the neuroendocrine, autonomic, immune and behavioral response to stress. CRF exerts its action through two major receptor, corticotropin-releasing factor 1 receptor (CRF-R1) and corticotropin-releasing factor 2 receptor (CRF-R2). Using two types of chronic stress models, we investigated the changes of CRF-R1 mRNA and CRF-R2 mRNA expressions and CRF mRNA in the stress related brain circuit areas Methods: Male Sprague-Dawley rats were exposed to either immobilization stress or variable intermittent unpredictable stress for 10 days and then in situ hybridization histochemistry was used to quantify CRF expression in the brain. Results: 1) CRF-R1 mRNA expressions were decreased in bed nucleus of the stria terminalis (BNST) following stressors. 2) CRF-R2 mRNA expressions were increased in lateral septum following stressors. 3) CRF mRNA expressions were increased in central nucleus of amygdala (CeA) and BNST. Results: The increased CRF mRNA of CeA and BNST may be related with anxiety response in the repeated stress. Down-regulation of CRF-R1 mRNA expression in BNST may represent a compensatory adaptation to chronic stress and may be involved in the anxiety response, whereas up-regulation of CRF-R2 mRNA expression in lateral septum may represent an anxiety response or impaired learning though the functional meaning is uncertain. Key words. Stress Corticotropin releasing factor lateral septum BNST amygdala in situ hybridization CRF 서 론

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