Association between obesity and impaired lung function in general population
- 주제(키워드) Obesity , lung function
- 발행기관 고려대학교 대학원
- 지도교수 최상은
- 발행년도 2017
- 학위수여년월 2017. 8
- 학위구분 석사
- 학과 대학원 약학과
- 원문페이지 37 p
- 실제URI http://www.dcollection.net/handler/korea/000000077222
- 본문언어 영어
- 제출원본 000045915582
초록/요약
Our study examined whether two different indices of obesity, body mass index (BMI) and waist circumference (WC), are associated with impaired lung function including airway restriction and obstruction among the general population in South Korea. Data analyzed from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2013 to 2015 included 8,827 participants over 40 years of age. Participants, completing a spirometry test and questionnaire with measurements of height, weight, WC, and smoking status, were included in the analysis. Airway restriction was defined as predicted FEV1 > 70% and predicted FVC < 80%, and airway obstruction was defined as FEV1/FVC ratio < 70%. A logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs) as measures of an association of airway restriction and obstruction with obesity. Compared to the low risk WC group, the high risk WC group had an OR of 1.26 (95% CI, 1.03 to 1.54) for airway restriction. Similarly, the overweight/obese group (BMI > 25 kg/m2) had an airway restriction OR of 1.46 (95% CI, 1.01 to 2.11) compared to the normal BMI group. The obese group also had an OR of 0.64 (95% CI, 0.42 to 0.98) for airway obstruction compared to normal BMI group. However, there was no significant difference among WC groups with regard to airway obstruction. Our study demonstrates that obesity is regarded as a risk factor for airway restriction, but different results regarding association between obesity and airway obstruction were found; No significant difference is apparent between WC and airway obstruction, while BMI is shown to have an impact on reducing airway obstruction.
more목차
1. Abstract 1
2. Introduction 2
3. Methods 5
3.1. Data Source and Participants’ Characteristics 5
3.2. Definition of Variables 6
3.3. Statistical Analyses 8
4. Results 9
4.1. Baseline Characteristics 9
4.2. FVC, FEV1,and FEV1/FVC ratio in males and females 12
4.3. FVC, FEV1, and FEV1/FVC ratio among age group 16
4.4. Odds ratios for obesity and pulmonary function 17
5. Discussion 23
6. Conclusion 28
7. References 29
국문요약 32
