Associations between interleukin-10 polymorphisms and vasculitis: A meta-analysis
- 주제(키워드) interleukin 10 polymorphism , vasculitis
- 발행기관 고려대학교 대학원
- 지도교수 이영호
- 발행년도 2015
- 학위수여년월 2015. 8
- 학위구분 석사
- 학과 대학원 의학과
- 세부전공 내과학 전공
- 원문페이지 40 p
- 실제URI http://www.dcollection.net/handler/korea/000000059762
- 본문언어 영어
- 제출원본 000045851106
초록/요약
Objective: The aim of this study was to perform a meta-analysis of eligible studies to derive a precise estimate of the association between interleukin-10 (IL-10) and susceptibility to vasculitis. Methods: Meta-analyses were conducted on the associations between vasculitis and the +1136 G/A (rs1518111), -819 C/T (rs1800871), -592 C/A (rs1800872), and -1082 G/A (rs1800896) polymorphisms in IL-10. Results: A total of 7,257 vasculitis patients and 8,474 controls in 21 eligible studies were included in the current meta-analysis. This meta-analysis showed significant associations between IL-10 at position +1136 G/A, -819 C/T, and -592 C/A and overall vasculitis (OR 1.32, 95% CI 1.19-1.48, P < 0.00001; OR 0.77, 95% CI 0.68-0.88, P=0.0002; OR 0.81, 95%CI 0.71-0.90, P=0.003), but no association between the IL-10 -1082 G/A polymorphism and vasculitis. On subgroup studies, significant associations were found between the +1136 G/A, -819 C/T, and -592 C/A polymorphisms and susceptibility to Beh?et’s disease. There were also significant association between the -592 C/A polymorphism and giant cell arteritis, and between a part of the -1082 G/A polymorphism and ANCA-associated vasculitis. Ethnicity-specific meta-analysis revealed significant associations between the +1136 G/A polymorphism and vasculitis in Asian populations, as well as between the +1136 G/A, -819 C/T, and -592 C/A polymorphisms and vasculitis in Middle Eastern populations. European populations had no association with any IL-10 polymorphisms. Conclusion: Meta-analysis demonstrates that the IL-10 +1136 G/A, -819 C/T, and -592 C/A polymorphisms are significantly associated with susceptibility to vasculitis.
more목차
1. Introduction
2. Methods
1) Identification of eligible studies and data extraction
2) Evaluation of statistical associations
3) Evaluation of publication bias
3. Results
1) Studies included in the meta-analysis
2) Meta-analysis of relationships between the IL-10 +1136 G/A, -819 C/T, -592 C/A, and -1082 G/A polymorphisms and overall vasculitis
3) Meta-analysis of relationships between the IL-10 +1136 G/A, -819 C/T, -592 C/A, and -1082 G/A polymorphisms and vasculitis in ethnicity groups
4) Meta-analysis of relationships between the IL-10 +1136 G/A, -819 C/T, -592 C/A, and -1082 G/A polymorphisms and vasculitis subgroups
5) Heterogeneity and publication bias
4. Discussion
5. References
