Prognostic Significance of Reactive Oxygen Species Modulator-1 (Romo1) Expression in Patients with Non-small Cell Lung Cancer
수술적 절제를 시행한 비소세포폐암 환자에서 Reactive Oxygen Species Modulator-1(Romo1)의 발현이 가지는 임상적 중요성
- 주제(키워드) lung cancer , reactive oxygen species , Romo1
- 발행기관 고려대학교 대학원
- 지도교수 인광호
- 발행년도 2014
- 학위수여년월 2014. 8
- 학위구분 박사
- 학과 일반대학원 의학과
- 세부전공 내과학
- 원문페이지 38 p
- 실제URI http://www.dcollection.net/handler/korea/000000052531
- 본문언어 영어
- 제출원본 000045808068
초록/요약
Background: Recently, the 'ROS modulator 1 (Romo1)' protein that modulates cellular ROS level was identified. The objective of this study is to clarify the relationship between Romo1 expression and the prognosis of non-small cell lung cancer patients. Materials and Methods: The expressions of Romo1 were evaluated by immunohistochemistry in surgical specimens obtained from the patients with adenocarcinoma or squamous cell carcinoma. H-score was calculated in each specimen, and the patients were classified into low- and high-expression groups. Factors associated with disease recurrence and mortality were statistically analyzed in association with Romo1 expression. Results: Survival analysis was performed in 110 patients and patients with H-score ≥165 were considered as high Romo1 expression group. Recurrence and mortality were higher in the patients with high Romo1 expression. Factors associated with disease recurrences were advanced stage ≥IIIA (adjusted HR 6.11; 95% CI, 1.04 – 35.92), T stage ≥ pathologic T2 (adjusted HR 5.25; 95% CI, 1.38 – 20.01), vascular invasion (adjusted HR 8.27; 95% CI, 1.24 – 55.39), adenocarcinoma (adjusted HR 4.24; 95% CI, 1.21 – 14.89), and high H-score ≥165 (adjusted HR 6.23; 95% CI, 1.93 – 20.12). Higher mortality was associated with advanced stage ≥IIIA (adjusted HR 17.48; 95% CI, 2.68 – 114.17), vascular invasion (adjusted HR 10.56; 95% CI, 1.31 – 85.42), adenocarcinoma (adjusted HR 5.09; 95% CI, 1.38 – 18.80), and high H-score ≥165 (adjusted HR 4.89; 95% CI, 1.15 – 20.79). Female patients, ever smoker, and higher T stage (≥ pathologic T2) were positively correlated with high Romo1 expression. Conclusions: High Romo1 expression may be an independent prognostic factor in patients with resectable non-small cell lung cancer.
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KOREAN ABSTRACT -------------------------- i
ABSTRACT ---------------------------------- iii
I. INTRODUCTION ------------------- 1
II. MATERIALS AND METHODS ------- 3
III. RESULTS ------------------------- 6
IV. DISCUSSION ---------------------- 9
V. CONCLUSIONS ------------------- 14
VI. TABLES -------------------------- 15
VII. FIGURES ------------------------- 20
VIII. REFERENCES -------------------- 25
