두피 건선에서 피부 건조도와 보습치료의 효과에 대한 연구
Evaluation of the degree of skin dryness and the effect of moisturizing therapy in scalp psoriasis
- 주제(키워드) scalp psoriasis , dryness , capacitance , sebum content , transepidermal water loss , moisturizing therapy
- 발행기관 고려대학교 대학원
- 지도교수 송해준
- 발행년도 2014
- 학위수여년월 2014. 8
- 학위구분 석사
- 학과 일반대학원 의학과
- 세부전공 피부과학 전공
- 원문페이지 42 p
- 실제URI http://www.dcollection.net/handler/korea/000000051855
- 본문언어 한국어
- 제출원본 000045808016
초록/요약
Background: Most of patients showed scalp involvement and it is one of the most challenging conditions in psoriasis. Dryness of skin is well known aggravating factor of psoriasis. Strangely enough, mainstay of scalp psoriasis treatment has been focused only on suppression of inflammation without serious attempt to moisturize scalp skin. Objective: An aim of the study was to investigate the degree of skin dryness and the effect of emollients in scalp psoriasis for arousing the necessity of moisturizing therapy Methods: Parameters of surface hydration of lesional and normal-looking skin was assessed by electronic measurement of the capacitance, sebum content, and trans-epidermal water loss (TEWL) for 15 scalp psoriasis patients and 15 persons in control group before and after two weeks of moisturizing therapy. Results: The psoriatic lesions on scalp showed lower degree of hydration than the lesions in other part of the body. Comparing with normal scalp skin, psoriatic lesions on scalp showed lower capacitance (38%), decreased sebum level (29%), and increased TEWL (203%). The lesions of scalp showed lower capacitance (52%), decreased sebum (40%), higher TEWL (168%) than uninvolved scalp skin. Interestingly, comparing with normal scalp, uninvolved (normal-looking) scalp skin of psoriatic patients revealed decreased capacitance (73%), decreased sebum level (72%), and increased TEWL (121%). After 2 weeks of moisturizing therapy, significant improvement (33% increase of capacitance, 34% increase of sebum level, 18% decrease of TEWL) of impaired hydration status was noticed in lesions of scalp psoriasis patients. Conclusion: Psoriatic scalp is far drier than psoriatic skin of the other parts of the body. Even in uninvolved area, scalp skin is suffered from lower degree of hydration. Complementary moisturizing therapy for whole scalp including uninvolved skin is mandatory to restore impaired skin barrier functions and to prevent further aggravation by untoward influence of topical steroid.
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