Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients
- 주제(키워드) Hemodialysis , Anemia , Hemoglobin , Mortality
- 발행기관 고려대학교 대학원
- 지도교수 권영주
- 발행년도 2014
- 학위수여년월 2014. 8
- 학위구분 석사
- 학과 일반대학원 의학과
- 세부전공 내과학
- 원문페이지 30 p
- 실제URI http://www.dcollection.net/handler/korea/000000051576
- 본문언어 영어
- 제출원본 000045808070
초록/요약
Background: Anemia is a major risk factor contributing to mortality in chronic kidney disease patients. There is controversy over the optimal hemoglobin (Hb) target in these patients. This study investigated the association between Hb level and mortality in a cohort of hemodialysis (HD) patients in Korea. Methods: This study was a multicenter prospective observational study of maintenance HD patients, performed in western area of Seoul, Korea over five years. A total of 252 participants were enrolled. Laboratory values and mortality were accessed every six months. Repeated measures of laboratory values in each interval were averaged to obtain one semiannual mean value. Hb values were divided into six groups (<9 g/dL, 9–10 g/dL, 10–11 g/dL, 11–12 g/dL, 12–13 g/dL, and ≥13 g/dL). We analyzed the odds ratio for all-cause mortality according to the Hb group, adjusting for demographics and various laboratory values. Statistics were carried out with SAS, version 9.1. Results: Mortality odds ratios relative to the reference group (10–11 g/dL) in the fully adjusted model were: 3.61 for <9 g/dL, 3.17 for 9–10 g/dL*, 4.65 for 11–12 g/dL*, 5.50 for 12–13 g/dL*, and 2.05 for ≥13 g/dL (*p value <0.05). Conclusions: In this study, a Hb level of 10-11 g/dL was associated with the lowest mortality among the groups with Hb <13 g/dL. Larger interventional trials are warranted to determine the optimal Hb target for Korean HD patients.
more목차
I. Introduction .................................1
II. Methods ....................................3
III. Results .....................................6
IV. Discussion ...............................8
V. References ...............................13
