PET/CT상의 대사성 종양 용적과 자궁경부암 환자의 임상적 매개변수간의 상관관계
The correlation between metabolic tumor volume on PET/CT and clinical parameters of patients with cervical cancer
- 주제(키워드) cervical cancer
- 발행기관 고려대학교 의학전문대학원
- 지도교수 송재윤
- 발행년도 2014
- 학위수여년월 2014. 2
- 학위구분 석사
- 학과 의학전문대학원 의학과
- 원문페이지 25 p
- 실제URI http://www.dcollection.net/handler/korea/000000050344
- 본문언어 영어
- 제출원본 000045795172
초록/요약
Abstract The correlation between metabolic tumor volume on PET/CT and clinical parameters of patients with cervical cancer Karam Kang, Yoon Byoung Kim, Ye Won Chung, Hyo Sook Bae, Jae Yoon Song Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea Conflict of Interest statement: The authors declare that there are no conflicts of interest. Objective The purpose of this study was to evaluate the value of metabolic tumor volume (MTV) of PET/CT in patients with cervical cancer. Material and Method Forty six patients who underwent PET/CT and MRI to evaluate cervical cancer were included from March 2008 to June 2011. We analyzed age, weight, height, parity, cancer type, cancer stage, MRI findings, PET findings of patients, retrospectively. Result The mean age of patients was 52.3±13.5. Patients were divided into two groups based on the median MTV value; low group (LG) and high group (HG) (median value: 83.6). There were no differences in age, BMI, parity, and cancer cell type between two groups. In the HG, clinical stage I and II were 78.9% (15 patients), stage III and IV were 21.1% (4 patients), where as in the LG, stage I and II were 100% (19 patients), none were in stage III and IV. The stage of the LG is significantly lower than that of the HG (p=0.03). Between the two groups, there was a significant difference in parametrium involvement (LG (47.4%) vs. HG (94.7%), p<0.01) and pelvic lymph node metastasis on MRI (LG (42.1%) vs. HG (78.9%), p=0.02). In addition, the HG value was significantly higher in tumor mass volume on MRI, and in the standardized uptake value (SUVmax) of primary tumor and pelvic lymph node. (p<0.01, <0.01, =0.04, respectively). The serum SCC level was higher in the HG, and was statistically significant (p<0.01). Conclusion Higher MTV correlates to parametrium involvement, pelvic node metastasis, and cancer stage in cervical cancer patients. And tumor mass volume on MRI, SUVmax of primary cancer lesion and pelvic lymph node, and serum level of SCC were higher in the HG. We concluded that MTV is an important factor which correlates with many clinical parameters in cervical cancer. The MTV cut off value of 83.6 was meaningful in this study.
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Table of Content
Abstract ………………………………………………………………….….. i
Introduction ….……………………………………………………….…...... 1
Materials and methods
1. Patients ……………………………………………………..…… 3
2. PET/CT technique …………………………………………….… 3
3. Image analysis ………………………………………………...… 4
4. Quantifying the tumor volume ………………………………….. 5
5. Statistical analysis …………………………………………….… 5
Results ………………………..…………………………………………...… 6
Discussion ………………………………………………………………….... 7
References …………………………………………………………………. 13
