Outcomes of Endoscopic treatment for Upper gastrointestinal neuroendocrine tumors
- 주제(키워드) Neuroendocrine tumor , upper gastrointestinal tract , Endoscopic treatment
- 발행기관 고려대학교 대학원
- 지도교수 박종재
- 발행년도 2013
- 학위수여년월 2013. 8
- 학위구분 석사
- 학과 일반대학원 의학과
- 세부전공 내과학
- 원문페이지 28 p
- 실제URI http://www.dcollection.net/handler/korea/000000045899
- 본문언어 영어
- 제출원본 000045761843
초록/요약
Outcomes of Endoscopic treatment for Upper Gastrointestinal Neuroendocrine Tumors Ho Kim, M.D. Major in Internal medicine, Department of Medical Science Graduate School, Korea University Seoul, Korea ( Director : Professor Jong Jae Park, M.D.,Ph.D.) Background/Aims: The treatment of gastrointestinal neuroendocrine tumors (NETs) was considered to be surgically excised except tumors less than 10 mm and limited to submucosal layer. The incidence of NET has increased, however upper gastrointestinal (UGI) NETs are considered uncommon and the reported incidence is 10-30% of all gastrointestinal NETs. In this study, we aimed to evaluate the clinical outcome of endoscopic treatment of UGI NETs. Methods: 27 patients diagnosed as UGI NETs were enrolled between April 2002 and June 2013. They underwent endoscopic removal. We reviewed their medical records including clinicopathologic characteristics, complete resection rate, recurrence rate and complications. Results: The mean age was 58.6±8.4 years old, and male:female ratio was 18:9. Only 6 patients had significant symptoms (5 with abdominal pain and 1 with dyspepsia). The location of the lesions was stomach in 14 cases (51.9%; 10 in corpus, 2 in antrum, and 2 in cardia) and duodenum in 13 cases (48.1%; 11 in bulb and 2 in the 2nd portion). The mean tumor size was 11.3±8.6mm. 16 cases were removed by endoscopic submucosal dissection (ESD) and 11 cases by endoscopic mucosal resection (EMR). The mean procedure time was 27.1±18.7 minutes. Complete resection was achieved in all lesions. Mean follow-up period was 17.2±15.2 months and recurrent case was not found. Major procedure-related complication was developed in 3 cases (two cases with macroperforation, and the other case with microperforation). Conclusion: Endoscopic treatment might be considered as an optimal therapeutic plan of non-metastatic gastric NETs lesser than 2.0cm and locoregional duodenal NETs.
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Contents
Abstract ……………………………….......………… i
I. INTRODUCTION ……………….…….………… 1
II. PATIENTS AND METHODS …….………….…. 2
III. RESULTS ………………………….…….……... 6
IV. DISCUSSION …………………….…….……… 11
V. REFERENCES ……………. ..………………… 17
