Association between vasomotor symptoms and insulin resistance in early menopausal Korean women
- 주제(키워드) vasomotor symptom , insulin resistance , menopause , menopause rating scale
- 발행기관 고려대학교 대학원
- 지도교수 김탁
- 발행년도 2013
- 학위수여년월 2013. 8
- 학위구분 석사
- 학과 일반대학원 의학과
- 세부전공 산부인과학 전공
- 원문페이지 24 p
- 실제URI http://www.dcollection.net/handler/korea/000000045789
- 본문언어 영어
- 제출원본 000045761831
초록/요약
Background/Aims: Vasomotor menopausal symptoms (VMS) are one of the most commonly reported symptoms in menopausal women, but only few studies exist about the relationship between VMS and insulin resistance. The aim of this study was to evaluate the association between VMS and insulin resistance, which can be postulated by fasting glucose level and homeostasis model assessment (HOMA) index, in early menopausal women. Methods: The participants included early menopausal women who have experienced last menstrual period 1 to 5 years ago, between 45 and 55 years old, who visited the institution from January 2010 to December 2012. To assess menopausal symptoms, all participants were required to complete a menopause rating scale (MRS) questionnaire. HOMA, an index derived from glucose and insulin measures ─ reflecting insulin resistance, was calculated by using the formula [(fasting insulin*fasting glucose)/405]. Results: The mean age of the total 529 participants were 48.2 ± 4.2 years. The average of total scores of MRS were 10.96 ± 7.00. The HOMA tended to increase in participants who reported high scores of MRS questionnaire 1 (MRS 1). In logistic regression, high scores of MRS 1 were significantly associated with the value of HOMA (t=3.438, P=0.001). The HOMA index seemed to be increased as the scores of MRS 1 increase (β=0.208). Conclusions: In this study, vasomotor symptoms in early postmenopausal women are associated with increased insulin resistance. VMS and insulin resistance have relationship in many metabolic aspects.
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ABSTRACT .................................................................................. 4
1. INTRODUCTION ................................................................. 5
2. MATERIALS AND METHODS ..................................... 7
3. RESULTS ................................................................................ 10
4. DISCUSSION ......................................................................... 12
5. REFERENCES ...................................................................... 15
