섬망 환자의 항정신병 약물 치료 반응과 도파민 유전체 유전자 다형성
- 발행기관 고려대학교
- 발행년도 2004
- 학위명 박사
- 학과 및 전공 고려대학교 대학원:의학과 정신과학 전공
- 식별자(기타) DL:000005719284
- 본문언어 한국어
- 서지제어번호 000000880787
초록/요약 도움말
Objectives: Delirium is a common disorder characterized by the temporary disturbance of various cognitive functions. In general, symptoms can be treated by relatively low doses of antipsychotic drugs. This study investigated the efficacy of a typical antipsychotic drug, haloperidol and an atypical antipsychotic drug, risperidone in terms of the effective dosages and response time. And, author tried to investigate the relationships of dopamine transporter gene polymorphisms and the treatment response, response time and treatment doses. Method: Either haloperidol or risperidone was administered to the delirium patients. Delirium symptoms were closely monitored and measured on a daily basis until remission. In addition, genetic polymorphisms of dopamine transporters(DAT) were determined using polymerase chain reaction(PCR) method. Results: The average effective dosages of the drugs were 1.671.32 mg/day (haloperidol) and 1.191.32 mg/day (risperidone). There were no significant differences of drug response time and response rate according to dopamine transporter gene polymorphisms. 10/10 variant of dopamine transporter gene was 35 among 42 (79.2%) and 9/10 variant was 7 (20.8%). Conclusion: The results suggest that the efficacy of an atypical antipsychotic drug, risperidone is not significantly different from haloperidol in terms of the response time and response rate. There were no differences in response time and response rate according to dopamine transporter gene polymorphisms.
more