Microinflammation in hemodialysis patients is associated with increased CD14+CD16+ pro-inflammatory monocytes: Possible modification by on-line hemodiafiltration
- 주제(키워드) chronic inflammation , hemodialysis , on-line hemodiafiltration , monocytes , TNF
- 발행기관 고려대학교 대학원
- 지도교수 조상경
- 발행년도 2011
- 학위수여년월 2011. 8
- 학위구분 박사
- 학과 일반대학원 의학과
- 세부전공 내과학전공
- 원문페이지 40 p
- 실제URI http://www.dcollection.net/handler/korea/000000027013
- 본문언어 영어
- 제출원본 000045667842
초록/요약
Background: Increased percentage of pro-inflammatory CD14+CD16+ monocytes might contribute to inflammation in hemodialysis (HD) patients. The purpose of the study was to evaluate the possible contribution of pro-inflammatory monocytes to inflammation in HD patients and also to evaluate the effect of on-line hemodiafiltration (on-line HDF). Method: Flow cytometric detection of monocytes in patients undergoing HD, on-line HDF and healthy controls as well as plasma cytokines and cytokine mRNA measurement were performed. Results: Percent of pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly increased in HD patients. Intracellular cytokine staining showed pro-inflammatory monocytes were the predominant source of tumor necrosis factor-a (TNF-a). Percent pro-inflammatory monocytes positively correlated with plasma inflammatory cytokines. Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly decreased in on-line HDF patients. Conclusions: Increased pro-inflammatory monocytes are likely to contribute to inflammation in HD patients and beneficial effect of on-line HDF might be partially mediated by modulating the inflammatory response
more목차
Abstract --- i
Introduction --- 1
Materials and Methods --- 3
Results --- 7
Discussion --- 11
References --- 16
