패혈성 급성 신부전의 임상적 특징과 예후
Clinical Characteristics and outcomes of septic acute kidney injury
- 주제(키워드) Acute kidney injury , Sepsis , Mortality , Renal recovery
- 발행기관 고려대학교 대학원
- 지도교수 조상경
- 발행년도 2011
- 학위수여년월 2011. 2
- 학위구분 석사
- 학과 일반대학원 의학과
- 원문페이지 27 p
- 실제URI http://www.dcollection.net/handler/korea/000000024911
- 본문언어 영어
- 제출원본 000045635166
초록/요약
Purposes: This study was to determine the clinical characteristics and outcomes of critically ill patients with septic acute kidney injury (AKI) in comparison with non-septic AKI. Methods: We retrospectively collected data of patients with AKI who were ≥18 years of age and admitted to the intensive care unit (ICU) for ≥24 hours from 1 April 2007 to 31 December 2009, and compared the clinical characteristics and outcomes of patients with and without sepsis. Results: Of the 1075 patients, 333 had AKI, as defined by the RIFLE criteria, and 134 of them had AKI with sepsis. The predominant septic foci were thoracic and abdominal. Septic AKI had significantly higher SAPS II and SOFA scores, and required more mechanical ventilation and vasoactive drugs than non-septic AKI. Patients with septic AKI progressed more to the failure category of the RIFLE classification. Septic compared with non-septic AKI had a higher in-hospital mortality and required more RRT. Amongst survivors, patients with septic AKI were more likely to recover renal function. Finally, a higher SAPS II score, and a greater requirement for vasoactive drugs and RRT were independently associated with increased in-hospital mortality in septic AKI. Conclusions: Patients with septic AKI have a higher burden of illness with an increased risk of death, but renal function recovers better in survivors of septic AKI.
more목차
Abstract v
1. Introduction 1
2. Methods 2
3. Results 5
4. Discussion 7
5. Tables 13
6. References 17
