다중전극과 전도성 고분자를 이용한 약물 전달시스템의 구현을 위한 연구
- 발행기관 고려대학교 대학원
- 발행년도 2004
- 학위명 박사
- 학과 대학원:마이크로/나노시스템협동과정
- 식별자(기타) DL:000014914444
- 서지제어번호 000045209349
초록/요약
Controlled drug release is typically achieved by encapsulating drugs in polymers, which can control the release of the drug to the body over specific durations ranging from a day to several years. It is well known that the method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. For some drugs, there exists an optimum range of concentration in which the maximum therapeutic benefit is derived. Drug concentrations above this range can be toxic, while concentrations below this range may produce no therapeutic effect at all. Conventional drug delivery systems such as tablets or injections typically results in a drug delivery profile initially marked by a sharp increase in concentration to a peak above the therapeutic range. The drug concentration then continues to decrease until it falls below the therapeutic range. Therefore, The time spent in the optimum concentration range is short. Much of this work involves the use or development of condition polymer that releases drugs at a constant rate due to drug diffusion out of the polymer. Many researchers who research methods of achieving pulsative release has focused on polymeric materials that respond to specific stimuli. They have developed ways to take advantage of changes in a polymer's physical properties to release drugs or other compounds in response to changes in electric or magnetic fields. The objectives of this thesis were to design, fabricate, and characterize a DDS chip capable of achieving continuous release of chemical substances. The DDS chip consists of an array of multi-electrodes on glass wafer. Each electrode was covered with a thin layer of conductive polymer. The proposed release mechanism has no moving parts. Each electrode is independent, and electric potential was applied to an anode using a potentiostat. Future integration with microelectronic components may allow reservoirs to be opened on demand by a preprogrammed microprocessor, remote c
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목 차
ABSTRACT i
목차 iv
그림 목차 vi
표 목차 ix
제 1 장 서 론 1
제 2 장 DDS 연구 동향 4
2.1 약물 전달시스템(DDS) 분류 4
2.2 DDS 연구 동향 5
제 3 장 전기 중합법을 이용한 폴리피롤 합성 및 다중 채널 전극 제작 10
3.1 전도성 고분자의 특성 10
3.2 전도성 고분자인 폴리피롤 합성 및 산화·환원 특성 15
3.2.1 폴리피롤인 PPy(DBS) 합성 15
3.2.2 폴리피롤 전극의 산화·환원 특성 19
3.3 Au 전극표면에 전기 중합법을 이용한 폴리피롤 합성 22
3.4 약물 방출을 위한 다중 채널 전극 설계 및 제작 30
3.4.1 전극으로 사용되는 Au 산화 특성 31
3.4.2 절연막으로 polyimide 특성 32
제 4 장 국소마취제 lidocaine 약물 도핑 및 방출 35
4.1 Amide형 국소마취제 lidocaine 특성 35
4.2 폴리피롤 막에 lidocaine 약물 도핑 37
4.3 폴리피롤 막에 lidocaine 약물 방출 39
4.3.1 UV spectrometer를 이용한 약물 검출 39
4.3.2 농도에 따른 lidocaine 약물의 파장에 따른 흡광도 측정 41
4.3.3 폴리피롤 막에 정전압을 인가하여 lidocaine 약물 방출 43
제 5 장 결 론 46
참고 문헌 48
