Sphingosine 유도체들의 새로운 합성법 : Novel Synthon Of Sphingosine Derivatives
- 발행기관 고려대학교 대학원
- 발행년도 2004
- 학위명 박사
- 학과 대학원:화학과
- 식별자(기타) DL:000014914175
- 서지제어번호 000045213421
초록/요약
Sphingolipids are ubiquitous membrane components of essentially all eukaryotic cells and abundantly located in all plasma membranes as well as in some intracellular organells. It has been show to play a role in intracellular signaling pathway. We prepared N-Boc-phytoshingosine-3,4-thiocarbonate in two steps, which was a novel intermediate for the synthesis of various sphingosine derivatives.
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차 례
List of Figures 1
List of Schemes 2
Symbols and Abbreviations 3
국문 요약 4
영문 요약 6
I. 서 론
1. Sphingolipids 란? 1
2. Biologically active sphingolipids 5
2.1. Pathway of sphingolipid metabolism 6
2.2. Compartmentalized pathways of ceramide
signaling 7
2.3. 특정한 암에서 ceramide/spingosine-1-
sphosphate의 역할 8
3. KRN7000 10
4. 연구배경 12
Ⅱ. 결과 및 고찰
1. N-Boc-phytosphingosine-3,4-carbonate를 통한
새로운 phytosphingosine 유도체 합성 13
2. 새로운 KRN7000의 합성법 연구 27
Ⅲ. 결 론
Ⅳ. 실 험
1. 일반적인 실험 33
2. 합성 34
참고문헌
