뼈의 거대세포종에서 Ki-67과 Telomerase 발현; 임상적 특성, 방사선학적 분류 및 재발과의 연관성 : Expression of Ki-67 and Telomerase in Giant Cell Tumor of Bone; Correlation with Clinical Features, Radiologic Grade and Recurrence
- 발행기관 고려대학교
- 발행년도 2008
- 학위수여년월 2008. 2
- 학위명 석사
- 학과 대학원 의학과 병리학전공
- 식별자(기타) DL:000018611276
- 서지제어번호 000045444417
초록/요약
-Abstract_ Expression of Ki-67 and Telomerase in Giant Cell Tumor of Bone ; Correlation with Clinical Features, Radiologic Grade and Recurrence Young Sam Kwon, MD (Director: Professor Chul Hwan Kim, M.D, Ph.D.) Background and Purpose : Giant cell tumors (GCT) represent about 5% of bone neoplasm. Although these tumors typically are benign, their behavior can be aggressive and locally recurrent. Despite the studies of recurrence factors in GCT, there are no definite markers for their behavior in these tumors. This study evaluates the clinical features, radiologic grade and the expression of Ki-67 and telomerase for determining the correlation with their biologic behavior, especially the local recurrence. Materials and Methods : The records of sixteen cases who were diagnosed with GCT between 1994 and 2007 were analysed retrospectively. This study reviewed the clinical characters, radiologic grading according to Ennerking system and recurrence. Immunohistochemical stainings for Ki-67 and telomerase were done. Results : The patients were 9 men and 7 women. Three of these cases had a local recurrence. These tumors were developed in the long bones (11 cases), vertebral body (3 cases), hand phalanx (1 case) and rib (1 case). Radiologic grading according to Ennerking system had two cases in stage 1, eight cases in stage 2 and six cases in stage 3. One case of stage 1 and two cases of stage 3 were recurred at the same sites. Expression rate of Ki-67 labeling index in non-recurred cases was 10.9% and initial expression rate in recurred cases was 8.9%, final expression rate in recurred cases was 8.9%. Telomerase was 0.78%, 0.24% and 0.61%, respectively. There was no association between local recurrence and Ki-67 expression rates. However, the telomerase expression was increased in the final expression rate of recurred cases compared to the initial expression rate of recurred cases. Conclusion : Clinical features, radiologic grade and the expression of Ki-67 were not correlated with a local recurrence. However, this study suggests that telomerase may be a useful recurrence factor of GCT. Further study of telomerase with more recurrence cases will be necessary. Key words : Giant cell tumor of bone, Ki-67, Telomerase, Recurrence
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