진공성형을 이용한 인공심장용 삼엽식 고분자 판막과 하우징 개발에 관한 연구 : Study on the development of trileaflet polymer valve and housing manufacturing method using vacuum forming process for artificial heart
- 발행기관 고려대학교
- 발행년도 2007
- 학위수여년월 2007. 2
- 학위명 석사
- 학과 대학원 의학과 의용생체공학전공
- 식별자(기타) DL:000018551267
- 서지제어번호 000045344334
초록/요약
This paper is about the development of manufacturing and the assessment of artificial heart blood pump using vacuum forming process(VFP). The VFP has many advantages such as reduction of fabrication time and high reproducibility due to relatively easy and simple manufacturing process. Prior to blood pump that utilizes VFP, polyurethane (Pellethane 2363 80AE, Dow Chemical) sheet was prepared by extrusion. The sheets were heated and formed to mold shape by vacuum pressure. The vacuum formed(VF) blood pump fabrication is composed of two step method. First is the trileaflet polymer valve forming process and the second is the housing forming process. Finally the blood pump is assembled by joining VF housing with vacuum formed trileaflet polymer valve(VTV) using pellethatne solution. The pressure and the flow was measured in in vitro test and animal trial using blood pump assembled by joining VF housing with VTV and blood pump assembled by joining VF housing with bileaflet mechanical valve(BMV). Pressure drop through valve, regurgitation and other related coefficients were evaluated under constant pulsatile flow condition. The percent effective orifice area of blood pump with VTV was inferior to blood pump with MBV, but the increase of plasma free hemoglobin level which reflect blood damage was superior in blood pump with VTV. Blood pump with VTV has high productivity, and superior hemolysis property than blood pump with BMV. Therefore Vacuum forming process to blood pump application was successful. Low manufacturing cost and blood compatible vacuum formed blood pump shows the advantages of vacuum forming process, and such vacuum forming process can reduce the cost of artificial heart or ventricular assist device. These results give feasibility to short term application in animal trial in the near future, and to the clinical artificial heart development program. Blood pump fabrication method that utilizes VFP suggested above, is expected to give great impact in both biomedical and industrial areas.
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ABSTRACT
목 차
제 1장 서 론
1.1 연구 배경
1.2 연구 가설
1.3 연구 자료
제 2장 혈액펌프 제작
2.1 진공성형기
2.2 폴리우레탄 시트 제작
2.3 삼엽식 고분자 판막 제작
2.4 하우징 제작
2.5 혈액펌프 조립
새 책갈피29
새 책갈피30
제 3장 혈액펌프 평가 방법
3.1 삼엽식 고분자 판막
3.2 혈액펌프의 in vitro test
3.3 동물 실험
제 4장 결과 및 고찰
4.1 진공성형을 이용한 혈액펌프 제작
4.2 삼엽식 고분자 판막의 성능 평가
4.3 동물 실험
제 5장 결 론
참고문헌
그림 목차
